|
^ X-(beta) cell X-cells are retinal ganglion cells described by their linear summation receptive field response. They are numerous and have rather narrow receptive fields as opposed to Y-cells
^ X Chromosome A sex determining chromosome. Alleles on X-chromosome loci may be partly responsible for Leber optic atrophy.
^ X-inactivation A process by which one of the two copies of the X chromosome present in female mammals is inactivated. Skewed X-inactivation has been suggested as an epigenetic mechanism influencing LHON penetrance. However, studies have not supported this hypothesis.
Gavin Hudson, Valerio Carelli, Rita Horvath, Massimo Zeviani, Hubert J. Smeets, Patrick F. Chinnery. X-Inactivation patterns in females harboring mtDNA mutations that cause Leber hereditary optic neuropathy. Mol Vis. 2007 Dec 21;13:2339-43 PMID 18199976
^ X-linked
Hudson G, Keers S, Yu Wai Man P, Griffiths P, Huoponen K, Savontaus ML, Nikoskelainen E, Zeviani M, Carrara F, Horvath R, Karcagi V, Spruijt L, de Coo IF, Smeets HJ, Chinnery PF. Identification of an X-chromosomal locus and haplotype modulating the phenotype of a mitochondrial DNA disorder. Am J Hum Genet. 2005 Dec;77(6):1086-91. Epub 2005 Oct 11. PMID 16380918
The International Foundation for
Optic Nerve Disease
P. O. Box 777, Cornwall NY 12518, USA.
Phone/Fax: (845)5348606
Email: ifond@aol.com
Web site:
http://www.ifond.org/
IFOND is registered service mark of
The International Foundation for Optic Nerve Disease, est. October 1995.
Copyright 1999-2024, International Foundation for
Optic Nerve Disease.
The information contained on this website should not be considered medical guidance or professional advice. IFOND is not responsible for errors or omissions in information provided on this site or actions resulting from its use. IFOND does not publish all information from all available sources on optic nerve disease. IFOND is not responsible for the validity of the studies or reviews nor is it an advocate of studies or reviews mentioned on or linked from the IFOND web site. IFOND does not endorse or recommend participation in any particular clinical trial or treatment protocol which may be mentioned on this site. Direct any questions concerning your personal health to your appropriate health care professional.